755 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Resistance to HER2-targeted therapy

Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...

Arterial malformations which cause compression of the trachea or esophagus.

Vascular-Targeted Photodynamic Therapy (VTP)

Vascular Malformations as a Cause of Postpartum Hemorrhage

Uterine vascular malformations (UVM) leading to postpartum hemorrhage (PPH) are rare. The worldwide literature consists of case reports and small case series, and while the true incidence is unknown, it is likely to represent a very small proportion of causes of PPH. UVM can be congenital but are more commonly acquired when they tend to present with secondary PPH, although in rare instances the...

Extracranial vascular malformations (hemangiomas and vascular malformations) in children and adolescents – diagnosis, clinic, and therapy

The field of extracranial vascular anomalies is considered as special focus of pediatric otolaryngology and it has shown a rapid development during the last years. The reason for this interest is finally also due to the global acceptance of the classification introduced by the ISSVA (International Society for the Study of Vascular Anomalies). Hemangiomas are the most frequently observed vascula...